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Patent for Sale:

New type of layer silicate nanocomposites of polymer hydrogels and their use in tissue expanders    

New type of layer silicate nanocomposites of polymer hydrogels and their use in tissue expanders

Overview

Summary

Our partner, University of Szeged has developed a self-expanding material with potential use in medical practice, aesthetic applications. The R&D phase of development is finished, product development phase has started. Our client is looking for partners interested in developing tissue expanders and/or implants.


Background information

Hydrogels are cross-linked polymers having hydrophilic and hydrophobic parts in appropriate ratios, allowing them to swell in aqueous media to several times their original volume without either dissolving or changing their shape to any considerable extent. These materials are also termed "intelligent gels", because, depending on their composition, they perceive changes in one or several environmental parameters (temperature, pH, light, magnetic field, etc.) and respond with a functional reaction (swelling, shrinking, sol-gel conversion). Owing to their advantageous properties hydrogels are widely utilized in medicine (controlled drug release, wound treatment, contact lenses).


Innovation and main advantages of the technology

Experimental results of our partner show that nanocomposites composed of hydrogels synthetized by copolymerization of N-isopropylacrylamide, acrylamide and/or acrylic acid monomers and supplemented with hydrophobized layer silicates are well applicable to tissue expansion for the purpose of stimulating skin production. According to their studies, nanocomposites implanted subcutaneously retained their chemical stability throughout the period studied; the kinetics of welling is satisfactory, and, due to their mechanical and geometrical stability, nanocomposites ensure proportional skin expansion. The volume expansion of the filler containing polymer gel is higher than that of other similar materials described in the technical literature: it amounts to approximately 40 times bigger than its original volume.
The seller is interested in finding R&D partners for clinical trial.

Benefits:

- the implanted expander is extremely small
- it only requires a very small aperture for implantation, thus it means minimal surgical trauma
- regular fill-ups are not necessary, so it causes less pain and fear in children
- less post-operative follow-up represents time saved for the patient
- does not irritate the surrounding tissues and cells, thus it means a lower risk of infection from the implant
- the patient is spared the constant discomfort of tightness associated with fill-ups
- it is fast, simple and reliable
- higher expansion volume (about 40 times of its dry volume)

Primary Application of the Technology

Potential areas of use: polymer hydrogels in tissue expanders, implants.

Sought customers: Pharmaceutical/Biotech companies; Clinics, Hospitals dealing with medical devices

The Problem Solved by the Technology

The biggest problem of the commonly used tissue expanders and implants is that these tools have a relatively big size that requires a relatively big surgery gash and also periodical refilling during the time of skin expansion. Our clients’ invention is a new type of osmotic silicate hydrogel that eliminates these problems.

Competitive Advantage

Several properties of hydrogels make them suitable for health care applications and for contact with living tissues.

• They resemble living tissues not only in their ability to absorb large amounts of water, but also in being permeable to small molecules such as oxygen, nutrients and various metabolites.
• The soft, elastic material of swollen hydrogels does not irritate the neighboring tissues and cells and, due to its low surface tension attributable to its high water content, it reduces protein adsorption and denaturation.
• These gels are free of undesirable intermediates, residual initiators and monomers and manufactured in a variety of shapes and sizes.

Additional Information

Stage of development: Hydrogel preclinical tests have been completed, the R&D phase is finished, and the invention has entered the product development and product manufacturing phase. In parallel, clinical trials on the medical device should commence.